SEQ OR SUITE
The dedicated BIONUMERICS SARS-CoV-2 tool includes up-to-date comprehensive analytical analyses to study the prevalence and epidemiology of existing and new mutations on both a global and local level to track and assist in the prevention of further spreading of concerning viral variants.
COMPARISON WITH PUBLICLY AVAILABLE DATA
CHARACTERIZATION OF MUTATION IMPACT ON THE CODING PROTEIN
IDENTIFICATION OF KNOWN VARIANTS
DISCOVERY OF POTENTIAL NEW VARIANTS
EPIDEMIOLOGICAL VISUALIZATION OF THE TRANSMISSION CHAIN
ABOUT THE SARS-CoV-2 TOOL IN BIONUMERICS
BIONUMERICS comes with an underlying database, supporting the import and storage of ten thousands (genomic) SARS-CoV-2 sequences.
Sequence regions that encode for proteins are compared to the Wuhan reference strain or any other user-defined reference sequence. All mutation changes – the so-called variants – are stored inside the BIONUMERICS database.
The built-in analysis tools allow you to trace transmission history, identify modes of transmission,
and discover potential new variants based on the detected mutations.
Additional SARS-CoV-2 tool features include haplotype determination based on a set of
well-defined amino acid substitutions, and in-silico sequence extraction based on the
WHO-standard primer sequences.
The SARS-CoV-2 tool is not for diagnostic use.
Figure 1. Single Nucleotide Polymorphisms for B.1.1.7 (top), P.1 (middle), and B.1.351 (bottom), with reference strain (Wuhan-Hu-1).
Figure 2: Close-up of spike protein mutations. Mutations that alter the spike protein are of particular interest as these may increase the virus’ ability to attach to human cells, possibly reduce the effectiveness of vaccines or impact disease severity.
Figure 3: Minimum spanning tree of B.1.1.7, B.1.351, and P.1 variants and the Wuhan-Hu-1 reference strain (middle), clearly illustrating the presence of distinct viral outbreak clusters.