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SARS-CoV-2

VARIANT ANALYSIS

IN BIONUMERICS

AVAILABLE

WITH BIONUMERICS

SEQ OR SUITE

UPDATED REGULARLY

The dedicated BIONUMERICS SARS-CoV-2 tool includes up-to-date comprehensive analytical analyses  to study the prevalence and epidemiology of existing and new mutations on both a global and local level to track and assist in the prevention of further spreading of concerning viral variants.  

  • COMPARISON WITH PUBLICLY AVAILABLE DATA

  • CHARACTERIZATION OF MUTATION IMPACT ON THE CODING PROTEIN

  • IDENTIFICATION OF KNOWN VARIANTS

  • DISCOVERY OF POTENTIAL NEW VARIANTS

  • EPIDEMIOLOGICAL VISUALIZATION OF THE TRANSMISSION CHAIN

ABOUT THE SARS-CoV-2 TOOL IN BIONUMERICS

BIONUMERICS comes with an underlying database, supporting the import and storage of ten thousands (genomic) SARS-CoV-2 sequences.

 

Sequence regions that encode for proteins are compared to the Wuhan reference strain or any other user-defined reference sequence.  All mutation changes – the so-called variants – are stored inside the BIONUMERICS database.  

The built-in analysis tools allow you to trace transmission history, identify modes of transmission,

and discover potential new variants based on the detected mutations.  

Additional SARS-CoV-2 tool features include haplotype determination based on a set of

well-defined amino acid substitutions, and in-silico sequence extraction based on the

WHO-standard primer sequences.  

The SARS-CoV-2 tool is not for diagnostic use.

Fig1 Single Nucleotide Polymorphisms wit

Figure 1. Single Nucleotide Polymorphisms for B.1.1.7 (top), P.1 (middle), and B.1.351 (bottom), with reference strain (Wuhan-Hu-1).

Fig2 Close-up of spike protein SNPs with

Figure 2: Close-up of spike protein mutations. Mutations that alter the spike protein are of particular interest as these may increase the virus’ ability to attach to human cells, possibly reduce the effectiveness of vaccines or impact disease severity.

Fig3 Minimum Spanning Tree COVID with le

Figure 3: Minimum spanning tree of B.1.1.7, B.1.351, and P.1 variants and the Wuhan-Hu-1 reference strain (middle), clearly illustrating the presence of distinct viral outbreak clusters.  

WATCH HOW IT WORKS IN BIONUMERICS

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