BIONUMERICS 8.0

IS ONE UNIVERSAL PLATFORM

TO STORE AND ANALYZE

YOUR BIOLOGICAL DATA

AVAILABLE IN 

FOUR

CONFIGURATIONS

Powerful databasing, integrated networking and a wide range of analysis and decision-making tools, including data mining, querying, clustering, identification, statistics, and much more.

The unique power of BIONUMERICS 8.0 lies in its ability to combine information from various genomic and phenotypic sources into one global database and conduct conclusive analyses.

  Select the configuration that meets YOUR application needs   

Choose four straightforward configurations depending on your different application needs, with the SUITE offering all functionalities of GEL, MALDI and SEQ combined.

Each configuration has an optional COMPLIANT package which allows the entire BIONUMERICS 8 platform to be used in compliance with the strictest Good Manufacturing Practice regulations (GMP), such as FDA 21 CFR Part 11.

  BIONUMERICS GEL  

 

The golden standard for classic fingerprinting.

  • Import and normalize all types of gel and sequencer based electrophoresis patterns (PFGE, RAPD, rep-PCR, MLVA, MIRU-VNTR, DGGE,…) 

  • Automated selection of lanes, bands and peaks for a selection of up to 20 000 entries

  • Adjustable background subtraction, curve smoothing and spot removal

  • Polymorphism analysis

  • Search for discriminative bands/peaks between selected groups of patterns

  BIONUMERICS MALDI  

 

Power up your MALDI-TOF instrument for bacterial research applications.

  • Import of metadata and raw spectral data from MALDI TOF instruments (like bioMérieux VITEK® MS, RUO )

  • Predefined or custom processing templates to clean up raw spectral data  

  • Predefined or custom templates to create summary spectra  

  • Creation of peaks tables and run statistical analysis

  • Identification of biomarkers with statistical analyses, linear discriminant analysis (LDA), heat map, …

  • Explore a wide range of ordination, partitioning and group validation techniques

  • Create powerful charts and plots.

  • Validate your hypothesis with numerous statistical tests

  • Distinction groups of similar spectra with cluster analysis, principal component analysis (PCA), multidimensional scaling (MDS), …

  • Creation and validation of a reference database using machine learning algorithms such as Support Vector Machines and
    Naive Bayesian classifiers and identification of unknown samples against this reference database

Using the Antibiotics susceptibility plugin, cut-off values can be set to automatically convert antibiotic resistance data to SIR categories (Susceptible, Intermediate, Resistant), which can then be used for calculating dendrograms and to perform statistical analyses on. 

  BIONUMERICS SEQ  

 

The most comprehensive set of analysis tools for microbial WGS based typing.

  • wgMLST, wgSNP typing thanks to 42 available schemes

  • Combination of WGS data with traditional techniques in one database

  • Import of sequencing data from any NGS instruments, and Sanger sequencing data (MLST, MLVA)

  • Long reads and shorts reads hybrid assemblies

  • Running integrated pipelines on your own computer or on the calculation engine

  • Annotation of bacterial genomes

  • Prediction of resistance and virulence genes, and alternative typing methods (spa, serotyping, …) 

  • Primer design, restriction enzyme analysis, ORF determination, … 

  • WGS tools

  BIONUMERICS SUITE  

 

The only software platform that offers integrated analyses of

all major applications in microbial bioinformatics.

The BN suite configuration includes all above functionality in one powerful database platform,

to easily keep track on all experimental data for your strains. It has database tools to facilitate

biological data management, database screening, user management and decision making tools. 

  • 1D electrophoresis gels (PFGE)

  • Chromatographic and spectrometric profiles (MALDI-TOF)

  • WGS and Sanger sequences

  • Phenotype characters

  • Share databases over your network, or use the data exchange tools for external sharing with collaborators 

  • Online help 

1

  OPTIONAL WITH EACH CONFIGURATION: BIONUMERICS COMPLIANT  

 

Allows the BIONUMERICS platform to be used in compliance with the strictest

Good Manufacturing Practice regulations (GMP), such as FDA 21 CFR Part 11.

  • Full logging of all actions per user

  • Keep all versions for every changed object

  • View full editing history per object, per class of objects or for the entire database

  • Compare any two versions in a convenient report that highlights the changes, deletions and insertions in different colors

  • Create full detail XML reports of versions and comparisons between versions

  • Restore previous versions of objects after erroneous changes

  • Digitally sign objects that are final and approved

  WHICH CONFIGURATION IS RIGHT FOR ME?  

REQUEST A QUOTE OR A FREE TRIAL

BY CLICKING HERE

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